[HTML][HTML] Osteopontin, a bridge links osteoarthritis and osteoporosis

RJ Bai, YS Li, FJ Zhang - Frontiers in Endocrinology, 2022 - frontiersin.org
Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of
articular cartilage, inflammation, and changes in periarticular and subchondral bone of …

[HTML][HTML] Osteopontin: a bone-derived protein involved in rheumatoid arthritis and osteoarthritis immunopathology

BT Martín-Márquez, F Sandoval-García… - Biomolecules, 2023 - mdpi.com
Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and
pathological mechanisms that nowadays has gained relevance due to its role in the immune …

Association of osteopontin with osteoarthritis

C Cheng, S Gao, G Lei - Rheumatology international, 2014 - Springer
The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly
affects the older people. OA is becoming one of the major non-fatal health burdens of the …

[HTML][HTML] Extracellular calcium ion concentration regulates chondrocyte elastic modulus and adhesion behavior

X Shen, L Hu, Z Li, L Wang, X Pang, CY Wen… - International Journal of …, 2021 - mdpi.com
Extracellular calcium ion concentration levels increase in human osteoarthritic (OA) joints
and contribute to OA pathogenesis. Given the fact that OA is a mechanical problem, the …

OPN deficiency increases the severity of osteoarthritis associated with aberrant chondrocyte senescence and apoptosis and upregulates the expression of …

J Tian, C Cheng, SD Kuang, C Su… - Pain Research and …, 2020 - Wiley Online Library
Objectives. A recent work has reported that the elevated osteopontin (OPN) levels in the
articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) …

Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182

S Wu, J Luo, X Zhang, L Wang, L Cai, J Xu - Experimental Cell Research, 2024 - Elsevier
Osteoarthritis (OA) is the most common type of joint disease and the leading cause of
chronic disability among older adults. As an important component of the joint, synovium …

Menisectomized miniature Vietnamese pigs develop articular cartilage pathology resembling osteoarthritis

R Cruz, C Ramírez, OI Rojas, O Casas-Mejía… - … -Research and Practice, 2015 - Elsevier
Animal models have been used to understand the basic biology of osteoarthritis (OA) and
have helped to identify new candidate biomarkers for the early diagnosis and treatment of …

[HTML][HTML] Proteomic analysis of rat cartilage: the identification of differentially expressed proteins in the early stages of osteoarthritis

NM Parra-Torres, FE Cázares-Raga, JB Kouri - Proteome science, 2014 - Springer
Background Osteoarthritis (OA) is a chronic degenerative disease of the articular cartilage,
and its diagnosis is based on symptoms and radiological signs that are only present in the …

[HTML][HTML] Phosphorylation of osteopontin has proapoptotic and proinflammatory effects on human knee osteoarthritis chondrocytes

SG Gao, Y Yu, C Zeng, ST Lu… - Experimental and …, 2016 - spandidos-publications.com
The aim of the present study was to investigate the effects of phosphorylated osteopontin (p-
OPN) on apoptosis and pro-inflammatory cytokine expression in human knee osteoarthritis …

[HTML][HTML] 骨桥蛋白干预体外培养人膝骨关节炎软骨细胞蛋白多糖和Ⅱ 型胶原的表达

朱鹤远, 雷光华, 高曙光, 张方杰, 曾超, 张凯 - 中国组织工程研究, 2016 - cjter.com
骨桥蛋白干预体外培养人膝骨关节炎软骨细胞蛋白多糖和Ⅱ型胶原的表达 中国组织工程研究
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