Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

Abstract Chromosome 22q11. 2 deletion syndrome is a common syndrome also known as
DiGeorge syndrome and velocardiofacial syndrome. It occurs in approximately 1: 4000 …

Velocardiofacial syndrome, DiGeorge syndrome, and some other clinical syndromes have in
common a high frequency of hemizygous deletions of chromosome 22q11. 2. This deletion …

Summary Chromosome 22q11. 2 deletion syndrome is the most common microdeletion
syndrome in humans. The effects are protean and highly variable, making a unified …

BACKGROUND: Severe combined immunodeficiency (SCID) is a treatable, inherited lack of
cellular and humoral immunity caused by diverse mutations in several different genes and …

The clinical translation of regenerative-medicine products, including cell therapies,
therapeutic tissue engineering products, and human cell and tissue products, remains …

The purpose of this study was to characterize a large group of infants with complete
DiGeorge anomaly and to evaluate the ability of thymus transplantation to reconstitute …

Severe combined immunodeficiencies (SCIDs) consist of genetically determined arrest of T‐
cell differentiation. Ten different molecular defects have now been identified, which all lead …