Polypharmacology: promises and new drugs in 2022
P Ryszkiewicz, B Malinowska, E Schlicker - Pharmacological Reports, 2023 - Springer
Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …
Antiandrogens as Therapies for COVID-19: A Systematic Review
M Cani, S Epistolio, G Dazio, M Modesti, G Salfi… - Cancers, 2024 - mdpi.com
Simple Summary The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic recently represented an unexpected global issue. Due to its rapid spread and …
pandemic recently represented an unexpected global issue. Due to its rapid spread and …
Gold-based metal drugs as inhibitors of coronavirus proteins: The inhibition of sars-cov-2 main protease by auranofin and its analogs
Gold compounds have a long tradition in medicine and offer many opportunities for new
therapeutic applications. Herein, we evaluated the lead compound Auranofin and five …
therapeutic applications. Herein, we evaluated the lead compound Auranofin and five …
A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
CA Amaya-Rodriguez, K Carvajal-Zamorano… - Frontiers in …, 2024 - frontiersin.org
The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …
Efficacy of bromhexine versus standard of care in reducing viral load in patients with mild-to-moderate COVID-19 disease attended in primary care: a randomized …
ML Vila Méndez, C Antón Sanz… - Journal of Clinical …, 2022 - mdpi.com
A 28-day randomized open-label multicenter study was conducted to assess the efficacy of
bromhexine plus standard of care (SOC)(n= 98) vs. SOC alone (n= 93) in 191 outpatients …
bromhexine plus standard of care (SOC)(n= 98) vs. SOC alone (n= 93) in 191 outpatients …
Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases
A Angarita-Rodríguez, JM Matiz-González, A Pinzón… - Pharmaceuticals, 2024 - mdpi.com
Astrocytes play a pivotal role in maintaining brain homeostasis. Recent research has
highlighted the significance of palmitic acid (PA) in triggering pro-inflammatory pathways …
highlighted the significance of palmitic acid (PA) in triggering pro-inflammatory pathways …
Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach
L Wang, A Chen, L Zhang, J Zhang, S Wei… - Frontiers in Molecular …, 2024 - frontiersin.org
Background The ongoing global health crisis of COVID-19, and particularly the challenges
posed by recurrent infections of the Omicron variant, have significantly strained healthcare …
posed by recurrent infections of the Omicron variant, have significantly strained healthcare …
Exploring the Therapeutic Potential of Spilanthol from Acmella paniculata (Wall ex DC.) RK Jansen in Attenuating Neurodegenerative Diseases: A Multi-Faceted …
SS Jayashan, N Darai, T Rungrotmongkol… - Applied Sciences, 2024 - mdpi.com
Neurodegenerative diseases (NDDs) are marked by progressive degeneration of neurons
within the central nervous system. A notable rise in the prevalence of NDDs has been …
within the central nervous system. A notable rise in the prevalence of NDDs has been …
[HTML][HTML] The crosstalk between phytotherapy and bioinformatics in the management of cancer
A Elbasyouni, SW Kpordze, HS Hussein… - Recent Advances in …, 2023 - intechopen.com
Natural products and medicinal plants have been extremely important contributors to the
field of drug development due to their ability to bind to and change cellular targets that have …
field of drug development due to their ability to bind to and change cellular targets that have …
[HTML][HTML] Magic bullets, magic shields, and antimicrobials in between
P Prathapan - Pharmaceutical Science Advances, 2023 - Elsevier
There are only two classes of small-molecule drugs for infectious disease: pathogen-
directed antimicrobials and host-directed immunomodulators. The former includes …
directed antimicrobials and host-directed immunomodulators. The former includes …