Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …

Simple Summary The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic recently represented an unexpected global issue. Due to its rapid spread and …

Gold compounds have a long tradition in medicine and offer many opportunities for new
therapeutic applications. Herein, we evaluated the lead compound Auranofin and five …

The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …

A 28-day randomized open-label multicenter study was conducted to assess the efficacy of
bromhexine plus standard of care (SOC)(n= 98) vs. SOC alone (n= 93) in 191 outpatients …

Astrocytes play a pivotal role in maintaining brain homeostasis. Recent research has
highlighted the significance of palmitic acid (PA) in triggering pro-inflammatory pathways …

Background The ongoing global health crisis of COVID-19, and particularly the challenges
posed by recurrent infections of the Omicron variant, have significantly strained healthcare …

Neurodegenerative diseases (NDDs) are marked by progressive degeneration of neurons
within the central nervous system. A notable rise in the prevalence of NDDs has been …

Natural products and medicinal plants have been extremely important contributors to the
field of drug development due to their ability to bind to and change cellular targets that have …

There are only two classes of small-molecule drugs for infectious disease: pathogen-
directed antimicrobials and host-directed immunomodulators. The former includes …