Statistical genetics and polygenic risk score for precision medicine
T Konuma, Y Okada - Inflammation and regeneration, 2021 - Springer
The prediction of disease risks is an essential part of personalized medicine, which includes
early disease detection, prevention, and intervention. The polygenic risk score (PRS) has …
early disease detection, prevention, and intervention. The polygenic risk score (PRS) has …
Multi-omics approach to precision medicine for immune-mediated diseases
M Ota, K Fujio - Inflammation and regeneration, 2021 - Springer
Recent innovation in high-throughput sequencing technologies has drastically empowered
the scientific research. Consequently, now, it is possible to capture comprehensive profiles …
the scientific research. Consequently, now, it is possible to capture comprehensive profiles …
Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses
Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
On cross-ancestry cancer polygenic risk scores
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification
and disease risk assessment, especially when combined with non-genetic risk factors …
and disease risk assessment, especially when combined with non-genetic risk factors …
Update on human genetic susceptibility to COVID-19: susceptibility to virus and response
VL Colona, V Vasiliou, J Watt, G Novelli… - Human genomics, 2021 - Springer
Update on human genetic susceptibility to COVID-19: susceptibility to virus and response |
Human Genomics Skip to main content SpringerLink Account Menu Find a journal Publish with …
Human Genomics Skip to main content SpringerLink Account Menu Find a journal Publish with …
COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy
G Novelli, M Biancolella, R Mehrian-Shai, VL Colona… - Human genomics, 2021 - Springer
COVID-19 has engulfed the world and it will accompany us all for some time to come. Here,
we review the current state at the milestone of 1 year into the pandemic, as declared by the …
we review the current state at the milestone of 1 year into the pandemic, as declared by the …
Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease
Background The value of polygenic risk scores (PRSs) towards improving guideline-
recommended clinical risk models for coronary artery disease (CAD) prediction is …
recommended clinical risk models for coronary artery disease (CAD) prediction is …
Homologous recombination DNA repair gene RAD51, XRCC2 & XRCC3 polymorphisms and breast cancer risk in South Indian women
T Rajagopal, A Seshachalam, KK Rathnam, S Talluri… - PLoS …, 2022 - journals.plos.org
Background Homologous recombination repair (HRR) accurately repairs the DNA double-
strand breaks (DSBs) and is crucial for genome stability. Genetic polymorphisms in crucial …
strand breaks (DSBs) and is crucial for genome stability. Genetic polymorphisms in crucial …
Bayesian approach to assessing population differences in genetic risk of disease with application to prostate cancer
IR Timmins, PRACTICAL Consortium… - Plos Genetics, 2024 - journals.plos.org
Population differences in risk of disease are common, but the potential genetic basis for
these differences is not well understood. A standard approach is to compare genetic risk …
these differences is not well understood. A standard approach is to compare genetic risk …
Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia
Background Susceptibility to severe hypertriglyceridemia (HTG), defined as plasma
triglyceride (TG) levels≥ 10 mmol/L (880 mg/dL), is conferred by both heterozygous rare …
triglyceride (TG) levels≥ 10 mmol/L (880 mg/dL), is conferred by both heterozygous rare …