Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

Focal copy-number increases (genomic amplification) pinpoint oncogenic driver genes and
therapeutic targets in cancer genomes. With the advent of genomic technologies, recurrent …

Gene amplification, which involves the two major topographical structures double minutes
(DMs) and homegeneously stained region (HSR), is a common mechanism of treatment …

A palindrome in DNA consists of two closely spaced or adjacent inverted repeats. Certain
palindromes have important biological functions as parts of various cis-acting elements and …

Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate
palindromic gene amplification, a common feature of cancer cells. Here, we show that small …

Dicentric chromosomes are unstable products of erroneous DNA repair events that can lead
to further genome rearrangements and extended gene copy number variations. During …

Evolution of the breast cancer genome from pre-invasive stages to asynchronous metastasis
is complex and mostly unexplored, but highly demanded as it may provide novel markers for …

Oncogene amplification confers a growth advantage to tumor cells for clonal expansion.
There are several, recurrently amplified oncogenes throughout the human genome …

Chromoanagenesis is a genomic event responsible for the formation of complex structural
chromosomal rearrangements (CCRs). Germline chromoanagenesis is rare and the majority …

Background: Microsatellite and chromosomal instability have been investigated in Hodgkin
lymphoma (HL). Materials and Methods: We studied seven HL cell lines (five Nodular …