The hypoxia-adenosine link during myocardial ischemia—reperfusion injury

W Ruan, X Ma, IH Bang, Y Liang, JD Muehlschlegel… - Biomedicines, 2022 - mdpi.com
Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …

Circadian gene variants in cancer

NM Kettner, CA Katchy, L Fu - Annals of medicine, 2014 - Taylor & Francis
Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …

Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice

J Espinoza-Derout, KM Hasan… - American Journal …, 2019 - journals.physiology.org
Electronic cigarettes (e-cigarettes), also known as electronic nicotine delivery systems, are a
popular alternative to conventional nicotine cigarettes, both among smokers and those who …

[HTML][HTML] The circadian clock regulates inflammatory arthritis

LE Hand, TW Hopwood, SH Dickson… - The FASEB …, 2016 - ncbi.nlm.nih.gov
There is strong diurnal variation in the symptoms and severity of chronic inflammatory
diseases, such as rheumatoid arthritis. In addition, disruption of the circadian clock is an …

Clock genes in hypertension: novel insights from rodent models

J Richards, AN Diaz, ML Gumz - Blood pressure monitoring, 2014 - journals.lww.com
The circadian clock plays an integral role in the regulation of physiological processes,
including the regulation of blood pressure. However, deregulation of the clock can lead to …

Circadian influences on myocardial ischemia-reperfusion injury and heart failure

T Eckle, J Bertazzo, TN Khatua… - Circulation …, 2024 - Am Heart Assoc
The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

Novel therapeutic strategies for cardioprotection

JPG Sluijter, G Condorelli, SM Davidson… - Pharmacology & …, 2014 - Elsevier
The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide.
The treatment for acute myocardial infarction has improved over the past decades, including …

Circadian rhythms in anesthesia and critical care medicine: potential importance of circadian disruptions

J Brainard, M Gobel, K Bartels, B Scott… - Seminars in …, 2015 - journals.sagepub.com
The rotation of the earth and associated alternating cycles of light and dark—the basis of our
circadian rhythms—are fundamental to human biology and culture. However, it was not until …

Transcription-independent induction of ERBB1 through hypoxia-inducible factor HIF2A provides cardio-protection during ischemia and reperfusion

JW Lee, M Koeppen, SW Seo, JL Bowser… - …, 2020 - pmc.ncbi.nlm.nih.gov
Background: During myocardial ischemia, hypoxia-inducible factors (HIFs) are stabilized
and provide protection from ischemia and reperfusion injury. Recent studies show that …

Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea

LS Gaspar, J Hesse, M Yalçin, B Santos… - …, 2021 - thelancet.com
Abstract Background Obstructive Sleep Apnea (OSA) is a highly prevalent and
underdiagnosed sleep disorder. Recent studies suggest that OSA might disrupt the …