CRISPR is becoming an indispensable tool in biological research. Once known as the
bacterial immune system against invading viruses, the programmable capacity of the Cas9 …

The clustered regularly interspaced short palindromic repeats/CRISPR-associated
(CRISPR/Cas) adaptive immune system has been extensively used for gene editing …

The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Mammalian genomes are folded into tens of thousands of long-range looping interactions.
The cause-and-effect relationship between looping and genome function is poorly …

Since the discovery that nucleases of the bacterial CRISPR (clustered regularly interspaced
palindromic repeat)‐associated (Cas) system can be used as easily programmable tools for …

Over a thousand diseases are caused by mutations that alter gene expression levels. The
potential of nuclease-deficient zinc fingers, TALEs or CRISPR fusion systems to treat these …

In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's
core was the modular assembly of regulators, operators, and structural genes. To illustrate …

The advent of high-throughput epigenome mapping technologies has ushered in a new era
of multiomics where powerful tools can now delineate and record different layers of genomic …

Cancers and developmental disorders are associated with alterations in the 3D genome
architecture in space and time (the fourth dimension). Mammalian 3D genome organization …

Nucleoprotein complexes play an integral role in genome organization of both eukaryotes
and prokaryotes. Apart from their role in locally structuring and compacting DNA, several …