The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Innate immune responses are regulated by microorganisms and cell death, as well as by a
third class of stress signal from the nervous and endocrine systems. The innate immune …

Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology,. Expression quantitative trait loci (eQTLs) help to explain the regulatory …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

A growing literature in human social genomics has begun to analyze how everyday life
circumstances influence human gene expression. Social-environmental conditions such as …

Although we generally experience our bodies as being biologically stable across time and
situations, an emerging field of research is demonstrating that external social conditions …

We analyzed the mRNA levels for 36,778 transcript expression traits (probes) from 2,765
individuals to comprehensively investigate the genetic architecture and degree of missing …

Genome-wide association studies (GWAS) are a standard approach for studying the
genetics of natural variation. A major concern in GWAS is the need to account for the …

Background Variability of gene expression in human may link gene sequence variability and
phenotypes; however, non-genetic variations, alone or in combination with genetics, may …

Numerous genetic loci have been associated with systolic blood pressure (SBP) and
diastolic blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide …