Click and bioorthogonal chemistry: the future of active targeting of nanoparticles for nanomedicines?

L Taiariol, C Chaix, C Farre, E Moreau - Chemical Reviews, 2021 - ACS Publications
Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Copper‐free click chemistry: applications in drug delivery, cell Tracking, and tissue engineering

HY Yoon, D Lee, DK Lim, H Koo, K Kim - Advanced Materials, 2022 - Wiley Online Library
Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

[HTML][HTML] Engineering the interface between inorganic nanoparticles and biological systems through ligand design

R Huang, DC Luther, X Zhang, A Gupta, SA Tufts… - Nanomaterials, 2021 - mdpi.com
Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological
applications. These applications are enabled through molecular design of surface …

[HTML][HTML] Fluorescence-Based Mono-and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells

WS Yun, H Cho, SI Jeon, DK Lim, K Kim - Biomolecules, 2023 - mdpi.com
The advancement of stem cell therapy has offered transformative therapeutic outcomes for a
wide array of diseases over the past decades. Consequently, stem cell tracking has become …

[HTML][HTML] Mesenchymal stem cell-mediated deep tumor delivery of gold nanorod for photothermal therapy

WS Yun, MK Shim, S Lim, S Song, J Kim, S Yang… - Nanomaterials, 2022 - mdpi.com
Gold nanoparticles (AuNPs) with various sizes and morphologies have been extensively
investigated for effective photothermal therapy (PTT) against multiple cancer types …

From bench to cell: a roadmap for assessing the bioorthogonal “click” reactivity of magnetic nanoparticles for cell surface engineering

J Idiago-López, E Moreno-Antolín, M Eceiza… - Bioconjugate …, 2022 - ACS Publications
In this work, we report the use of bioorthogonal chemistry, specifically the strain-promoted
click azide–alkyne cycloaddition (SPAAC) for the covalent attachment of magnetic …

Chemical reporters to study mammalian O-glycosylation

KE Huxley, LI Willems - Biochemical Society Transactions, 2021 - portlandpress.com
Glycans play essential roles in a range of cellular processes and have been shown to
contribute to various pathologies. The diversity and dynamic nature of glycan structures and …

Bioorthogonal Chemistry and Bioconjugation: Synergistic Tools for Biology and Biomedicine

J van Hest, G Zheng, VM Rotello - Bioconjugate Chemistry, 2021 - ACS Publications
Bioorthogonal chemistry provides a true nexus between chemistry and biology, using
abiological reactions developed by chemists to create new tools and techniques for biology …

Cellular uptake of FITC-labeled CeGdO nanoparticles in 2D and 3D mesenchymal stem cell systems

DD Kolmanovich, NN Chukavin, NA Pivovarov… - Наносистемы: физика …, 2024 - mathnet.ru
Cerium-containing nanoparticles have recently been identified as promising nanozymes for
advanced biomedical applications. Additional modification of the core or the surface of CeO …

[PDF][PDF] Developing chemical tools to study ribitol-5-phosphate within cell-surface glycans

K Huxley - 2022 - etheses.whiterose.ac.uk
Glycans play essential roles in a range of cellular processes and have been shown to
contribute to various pathologies. The diversity and dynamic nature of glycan structures and …