Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood
without replacement by bone marrow-derived circulating cells. In inflammation, stroke …

Dendrimers offer well-defined nanoarchitectures with spherical shape, high degree of
molecular uniformity, and multiple surface functionalities. Such unique structural properties …

Hyperinflammation triggered by SARS-CoV-2 is a major cause of disease severity, with
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …

Glioblastoma is among the most aggressive forms of cancers, with a median survival of just
15–20 months for patients despite maximum clinical intervention. The majority of …

Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …

Drug studies on Rett syndrome (RTT) have drastically increased over the past few decades.
This review aims to provide master data on bench-to-bedside drug studies involving RTT. A …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

Abnormalities in airway mucus lead to chronic disorders in the pulmonary system such as
asthma, fibrosis and chronic obstructive pulmonary disease (COPD). Among these, COPD is …

Glioblastoma exhibits high mortality rates due to challenges with drug delivery to the brain
and into solid tumors. This two-pronged barrier necessitates high doses of systemic …