Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease
Parkinson's disease (PD) is characterized by the progressive appearance of intraneuronal
Lewy aggregates, which are primarily composed of misfolded α-synuclein (α-syn). The …
Lewy aggregates, which are primarily composed of misfolded α-synuclein (α-syn). The …
Learning‐dependent neurogenesis in the olfactory bulb determines long‐term olfactory memory
S Sultan, N Mandairon, F Kermen, S Garcia… - The FASEB …, 2010 - Wiley Online Library
Inhibitory interneurons of the olfactory bulb are subjected to permanent adult neurogenesis.
Their number is modulated by learning, suggesting that they could play a role in plastic …
Their number is modulated by learning, suggesting that they could play a role in plastic …
[HTML][HTML] Neural processing of the reward value of pleasant odorants
Pleasant odorants are represented in the posterior olfactory bulb (pOB) in mice. How does
this hedonic information generate odor-motivated behaviors? Using optogenetics, we report …
this hedonic information generate odor-motivated behaviors? Using optogenetics, we report …
Population coding in an innately relevant olfactory area
Different olfactory cortical regions are thought to harbor distinct sensory representations,
enabling each area to play a unique role in odor perception and behavior. In the piriform …
enabling each area to play a unique role in odor perception and behavior. In the piriform …
Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb
W Zhang, C Sun, Y Shao, Z Zhou, Y Hou, A Li - Scientific Reports, 2019 - nature.com
Olfactory dysfunction is a major non-motor symptom that appears during the early stages of
Parkinson's Disease (PD), a neurodegenerative disorder characterized by loss of …
Parkinson's Disease (PD), a neurodegenerative disorder characterized by loss of …
Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging
Downregulation of insulin‐like growth factor (IGF) pathways prolongs lifespan in various
species, including mammals. Still, the cellular mechanisms by which IGF signaling controls …
species, including mammals. Still, the cellular mechanisms by which IGF signaling controls …
[HTML][HTML] Topographical representation of odor hedonics in the olfactory bulb
Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation
in freely behaving mice paired with immediate early gene mapping, we demonstrate that …
in freely behaving mice paired with immediate early gene mapping, we demonstrate that …
Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice
NL Rey, D Jardanhazi-Kurutz, D Terwel… - Neurobiology of …, 2012 - Elsevier
Neuronal loss in the locus coeruleus (LC) is 1 of the early pathological events in Alzheimer's
disease (AD). Projections of noradrenergic neurons of the LC innervate the olfactory bulb …
disease (AD). Projections of noradrenergic neurons of the LC innervate the olfactory bulb …
Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference
N Mandairon, S Sultan, M Nouvian… - Journal of …, 2011 - Soc Neuroscience
New neurons are continuously generated in the adult mammalian olfactory bulb. The role of
these newborn neurons in olfactory learning has been debated. Blocking the addition of …
these newborn neurons in olfactory learning has been debated. Blocking the addition of …
[HTML][HTML] Tropospheric ozone effect on olfactory perception and olfactory bulb dopaminergic interneuron excitability
Ozone (O 3) forms in the Earth's atmosphere, both naturally and by reactions of man-made
air pollutants. Deleterious effects of O 3 have been found in the respiratory system. Here, we …
air pollutants. Deleterious effects of O 3 have been found in the respiratory system. Here, we …