The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …

Background Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis.
Mepolizumab, an anti–interleukin-5 monoclonal antibody, reduces blood eosinophil counts …

Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Disease overview The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

Highlights•Solid organ transplantation (SOT) patients or patients with active ADs have been
largely excluded from ICIs clinical trials because of the risk of allograft rejection or severe …

Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis
of asthma, allergic and parasitic diseases, and hypereosinophilic syndromes, in addition to …

Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast,
inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of …

Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions.
Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to …