Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] Enterovirus A71 antivirals: past, present, and future
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …
immune escape. It remained unclear whether the emerging variants have gradually …
Distinct accumulation of nanoplastics in human intestinal organoids
Plastic particles, especially nanoplastics, represent an emerging concern of threat to human
health, oral uptake is an important pathway for the plastic particles ingestion by human …
health, oral uptake is an important pathway for the plastic particles ingestion by human …
Human intestinal organoids: promise and challenge
The study of human intestinal biology in healthy and diseased conditions has always been
challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro …
challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro …
Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
Organoids and colorectal cancer
A Barbáchano, A Fernández-Barral… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is one of the most frequent and lethal types of cancer.
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …
Listen to your gut: key concepts for bioengineering advanced models of the intestine
O Cameron, JF Neves, E Gentleman - Advanced Science, 2024 - Wiley Online Library
The intestine performs functions central to human health by breaking down food and
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …
Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids
J Moshiri, AR Craven, SB Mixon, MR Amieva… - Nature …, 2023 - nature.com
Enterovirus A71 causes severe disease upon systemic infection, sometimes leading to life-
threatening neurological dysfunction. However, in most cases infection is asymptomatic and …
threatening neurological dysfunction. However, in most cases infection is asymptomatic and …
Microbiome as an immune regulator in health, disease, and therapeutics
New discoveries in drugs and drug delivery systems are focused on identifying and
delivering a pharmacologically effective agent, potentially targeting a specific molecular …
delivering a pharmacologically effective agent, potentially targeting a specific molecular …