Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

The human six‐transmembrane epithelial antigen of the prostate (STEAP) protein family
contains at least five homologous members. The necessity of multiple homologous STEAP …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR)
activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in …

Prostate gland development is a complex process that involves coordination of multiple
signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription …

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …

Rationale: Cancer cells reprogram cellular metabolism to fulfill their needs for rapid growth
and metastasis. However, the mechanism controlling this reprogramming is poorly …

A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry
that is formed by a group of core transcription factors (TFs). These core TFs collectively …

Abstract Background Circular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) is
significantly down-regulated in various kinds of tumors, however, the mechanisms of action …