Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

SY Min, A Desai, Z Yang, A Sharma… - Proceedings of the …, 2019 - National Acad Sciences
Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of
cells required to mediate complex functions in multicellular organisms. Despite the multiple …

Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages

A Gupta, F Shamsi, N Altemose, GF Dorlhiac… - Genome …, 2022 - genome.cshlp.org
Single-cell RNA sequencing (scRNA-seq) enables molecular characterization of complex
biological tissues at high resolution. The requirement of single-cell extraction, however …

Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis

NF Denton, M Eghleilib, S Al-Sharifi… - International journal of …, 2019 - nature.com
Abstract Background Bone morphogenetic proteins (BMPs) regulate adipogenesis but it is
not clear whether they influence regional adipose tissue (AT) development in humans …

A novel role of Id1 in regulating oscillatory shear stress-mediated lipid uptake in endothelial cells

K Zhang, Y Chen, T Zhang, L Huang, Y Wang… - Annals of biomedical …, 2018 - Springer
Inhibitor of DNA binding 1 (Id1) has been shown to be involved in adipogenesis and
metabolism, which may contribute to atherosclerotic progression. However, it remains …

PGC1α cooperates with FOXA1 to regulate epithelial mesenchymal transition through the TCF4-TWIST1

XQ Fang, M Lee, WJ Lim, S Lee, CH Lim… - International journal of …, 2022 - mdpi.com
The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) is a
critical transcriptional coactivator that maintains metabolic homeostasis and energy …

[HTML][HTML] Noggin depletion in adipocytes promotes obesity in mice

AM Blázquez-Medela, M Jumabay, P Rajbhandari… - Molecular …, 2019 - Elsevier
Objective Obesity has increased to pandemic levels and enhanced understanding of
adipose regulation is required for new treatment strategies. Although bone morphogenetic …

BMP7 increases UCP1-dependent and independent thermogenesis with a unique gene expression program in human neck area derived adipocytes

A Shaw, BB Tóth, R Arianti, I Csomós, S Póliska… - Pharmaceuticals, 2021 - mdpi.com
White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown
and beige adipocytes mainly function in dissipating energy as heat primarily via the action of …

[HTML][HTML] 鸡脂肪组织TCF21基因启动子区DNA甲基化与其表达的关系

刘雨萌, 马艳艳, 姜海煦, 张心扬, 武春艳, 程博涵… - 畜牧兽医学报, 2021 - xml-data.org
旨在研究鸡脂肪组织中TCF21 基因启动子区DNA 甲基化水平与其表达的关系.
以东北农业大学高, 低腹脂双向选择品系(简称高, 低脂系) 第24 世代7 周龄肉鸡为试验材料 …

Multiple human adipocyte subtypes and mechanisms of their development

SY Min, A Desai, Z Yang, A Sharma, RMJ Genga… - bioRxiv, 2019 - biorxiv.org
Human adipose tissue depots perform numerous diverse physiological functions, and are
differentially linked to metabolic disease risk, yet only two major human adipocyte subtypes …

Upregulation of Inhibitor of DNA Binding 1 and 3 is Important for Efficient Thermogenic Response in Human Adipocytes

R Arianti, BÁ Vinnai, R Alrifai, G Karadsheh… - bioRxiv, 2024 - biorxiv.org
Brown and beige adipocytes can be activated by β-adrenergic agonist via cAMP-dependent
signaling. Performing RNA-sequencing analysis in human cervical area-derived adipocytes …