Transforming growth factor-beta (TGF-β) is a multifunctional regulatory polypeptide that is
the prototypical member of a large family of cytokines that controls many aspects of cellular …

Abstract In 2006, more than 55 000 patients died of colorectal cancer in the US, accounting
for∼ 10% of all cancer deaths. Despite significant progress in screening combined with the …

Preeclampsia, the major cause of maternal morbidity and mortality in developed countries, is
associated with abnormalities of placenta function due to shallow invasion of the maternal …

Resveratrol is a natural phytoalexin compound found in grapes and other food products. In
this study, the effect of resveratrol on the growth of human breast cancer cells was …

The TGF-βs are a family of cytokines with antiproliferative activity on many cell types. Recent
findings demonstrate that the TGF-β receptor complex functions as a tumor suppressor gene …

Transforming growth factor-beta (TGF-β) signaling is dependent on the heterodimerization of
the type II TGF-β receptor (TβRII) with the type I TGF-β receptor (TβRI). Activated TβRI then …

This article focuses on recent findings that the type V TGF‐β receptor (TβR‐V), which co‐
expresses with other TGF‐β receptors (TβR‐I, TβR‐II, and TβR‐III) in all normal cell types …

Tumor-initiating stem-like cells (TICs) are resistant to chemotherapy and associated with
hepatocellular carcinoma (HCC) caused by HCV and/or alcohol-related chronic liver injury …

Human pancreatic cancers overexpress a number of important tyrosine growth factor
receptors and their ligands. These include the epidermal growth factor (EGF) receptor …

Trans forming growth factor β (TGF-β) and related cytokines regulate cell fate by signalling
through two receptor serine kinases that act in sequence. Signalling by these receptors is …