[HTML][HTML] Advancements in acoustic drug delivery for paranasal sinuses: A comprehensive review
Chronic rhinosinusitis (CRS) impacts patients' quality of life and healthcare costs. Traditional
methods of drug delivery, such as nasal sprays and irrigation, have limited effectiveness …
methods of drug delivery, such as nasal sprays and irrigation, have limited effectiveness …
Characterizing regional drug delivery within the nasal airways
Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …
the site of deposition constitutes the first point of contact of the body with the drug …
Effect of MDI actuation timing on inhalation dosimetry in a human respiratory tract model
Accurate knowledge of the delivery of locally acting drug products, such as metered-dose
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …
Simulation of patient-specific bi-directional pulsating nasal aerosol dispersion and deposition with clockwise 45 and 90 nosepieces
Numerical simulations of the dispersion and deposition of poly-disperse particles in a patient-
specific human nasal configuration are performed. Computed tomography (CT) images are …
specific human nasal configuration are performed. Computed tomography (CT) images are …
Anatomical details of the rabbit nasal passages and their implications in breathing, air conditioning, and olfaction
The rabbit is commonly used as a laboratory animal for inhalation toxicology tests and detail
knowledge of the rabbit airway morphometry is needed for outcome analysis or theoretical …
knowledge of the rabbit airway morphometry is needed for outcome analysis or theoretical …
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Chronic and allergic rhinosinusitis impacts approximately 12% of the global population.
Challenges in rhinosinusitis treatment include paranasal sinus inaccessibility and variability …
Challenges in rhinosinusitis treatment include paranasal sinus inaccessibility and variability …
Effects of guiding vanes and orifice jet flow of a metered-dose inhaler on drug dosimetry in human respiratory tract
Accurate modeling and simulation of metered-dose inhaler (MDI) drug delivery require
detailed information about the spray aerosols and carrier airflows, which are sensitive to the …
detailed information about the spray aerosols and carrier airflows, which are sensitive to the …
The impact of geometrical parameters on acoustically driven drug delivery to maxillary sinuses
Acoustically driven nebulized drug delivery (acoustic aerosol delivery) is the most efficient
noninvasive technique for drug delivery to maxillary sinuses (MS). This method is based on …
noninvasive technique for drug delivery to maxillary sinuses (MS). This method is based on …
Understanding the mechanisms underlying pulsating aerosol delivery to the maxillary sinus: in vitro tests and computational simulations
Background Pulsating aerosol delivery has been demonstrated in depositing medications
into paranasal sinuses. However, its mechanisms are not fully understood. Influences of the …
into paranasal sinuses. However, its mechanisms are not fully understood. Influences of the …
Count-and mass-based dosimetry of MDI spray droplets with polydisperse and monodisperse size distributions
Most previous numerical studies of inhalation drug delivery used monodisperse aerosols or
quantified deposition as the ratio of deposited particle number over the total number of …
quantified deposition as the ratio of deposited particle number over the total number of …