[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis

CC Hughey, P Puchalska, PA Crawford - Biochimica et Biophysica Acta …, 2022 - Elsevier
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. NAFLD
includes non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NASH is …

Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases

B Dewidar, L Mastrototaro, C Englisch, C Ress… - …, 2023 - thelancet.com
Background Disturbed hepatic energy metabolism contributes to non-alcoholic fatty liver
(NAFLD), but the development of changes over time and obesity-or diabetes-related …

A low-carbohydrate diet with different fatty acids' sources in the treatment of obesity: Impact on insulin resistance and adipogenesis

AB Santamarina, LV Mennitti, EA de Souza… - Clinical Nutrition, 2023 - Elsevier
Background The search for nutritional intervention strategies against obesity has grown,
highlighting the low-carbohydrate diet model. However, little is known about the impact of …

[HTML][HTML] Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD

J Bilson, CJ Oquendo, J Read, E Scorletti, PR Afolabi… - Metabolism, 2024 - Elsevier
Background and aims Subcutaneous adipose tissue (SAT) dysfunction contributes to
NAFLD pathogenesis and may be influenced by the gut microbiota. Whether transcript …

[HTML][HTML] Diabetes as a risk factor for MASH progression

S Gancheva, M Roden, L Castera - Diabetes Research and Clinical …, 2024 - Elsevier
Abstract Non-alcoholic (now: metabolic) steatohepatitis (MASH) is the progressive
inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD) …

[HTML][HTML] Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH

M Boesch, A Lindhorst, R Feio-Azevedo, P Brescia… - Journal of …, 2024 - Elsevier
Background & Aims In non-alcoholic fatty liver disease (NAFLD), monocytes infiltrate
visceral adipose tissue promoting local and hepatic inflammation. However, it remains …

Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease

T Sarabhai, S Kahl, S Gancheva, L Mastrototaro… - Metabolism, 2024 - Elsevier
Background Obesity and type 2 diabetes frequently have metabolic dysfunction-associated
steatotic liver disease (MASLD) including steatohepatitis (MASH). In obesity, the liver may …

Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

M Flensted-Jensen, D Oró, EA Rørbeck, C Zhang… - BMC …, 2024 - Springer
Background Hepatocellular senescence may be a causal factor in the development and
progression of non-alcoholic steatohepatitis (NASH). The most effective currently available …

Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery

H Natsui, M Watanabe, T Yokota, S Tsuneta… - Physiological …, 2024 - Wiley Online Library
Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with
occurrence of atrial fibrillation (AF). However, the role of EAT in the development of …