In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Advanced metastatic cancer poses utmost clinical challenges and may present molecular
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …

Brain malignancies encompass a range of primary and metastatic cancers, including low-
grade and high-grade gliomas and brain metastases (BrMs) originating from diverse …

Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …