Glycosaminoglycans: what remains to be deciphered?
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …
diversity and fulfilling various functions mediated by thousands of interactions in the …
Oligosaccharide synthesis and translational innovation
L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer
W Yao, DC Xiong, Y Yang, C Geng, Z Cong, F Li… - Nature …, 2022 - nature.com
Carbohydrates play essential roles in nature, such as in cell–cell communication, cell growth
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …
Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactions
Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their
structural complexity has limited an understanding of their biological roles and structure …
structural complexity has limited an understanding of their biological roles and structure …
Glycans in drug discovery
P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …
Automated quantification of hydroxyl reactivities: Prediction of glycosylation reactions
The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable.
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …
Hierarchical and programmable one-pot synthesis of oligosaccharides
The programmable one-pot oligosaccharide synthesis method was designed to enable the
rapid synthesis of a large number of oligosaccharides, using the software Optimer to search …
rapid synthesis of a large number of oligosaccharides, using the software Optimer to search …
An efficient modular one-pot synthesis of heparin-based anticoagulant idraparinux
Idraparinux is a fully O-sulfated α-methyl glycoside of heparin pentasaccharide motif known
to interact with the antithrombin III domain and act as anticoagulant. The current most …
to interact with the antithrombin III domain and act as anticoagulant. The current most …
Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
NJ Pawar, L Wang, T Higo, C Bhattacharya… - Angewandte …, 2019 - Wiley Online Library
The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical
roles in many important biological processes. However, an understanding of their specific …
roles in many important biological processes. However, an understanding of their specific …
Programmable one-pot synthesis of heparin pentasaccharide fondaparinux
The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein
thrombosis and acute pulmonary embolism since 2002 and is considered to be better than …
thrombosis and acute pulmonary embolism since 2002 and is considered to be better than …