Mechanisms of decompensation and organ failure in cirrhosis: from peripheral arterial vasodilation to systemic inflammation hypothesis
The peripheral arterial vasodilation hypothesis has been most influential in the field of
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …
inflammation and altered immune processes underlie the development of pulmonary arterial …
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …
followed by a decompensated phase, marked by the development of overt clinical signs, the …
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
C Deng, Q Zhang, P He, B Zhou, K He, X Sun… - Nature …, 2021 - nature.com
Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid
arthritis (RA) joints contributes toward the persistent progression of joint inflammation and …
arthritis (RA) joints contributes toward the persistent progression of joint inflammation and …
Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases
Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …
Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction
C Engelmann, J Clària, G Szabo, J Bosch… - Journal of …, 2021 - Elsevier
Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …
Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart
I Vrhovac, D Balen Eror, D Klessen, C Burger… - … -European Journal of …, 2015 - Springer
Novel affinity-purified antibodies against human SGLT1 (hSGLT1) and SGLT2 (hSGLT2)
were used to localize hSGLT2 in human kidney and hSGLT1 in human kidney, small …
were used to localize hSGLT2 in human kidney and hSGLT1 in human kidney, small …
[HTML][HTML] Macrophages in pancreatitis: Mechanisms and therapeutic potential
F Hu, N Lou, J Jiao, F Guo, H Xiang, D Shang - Biomedicine & …, 2020 - Elsevier
Macrophages play a crucial role in the pathogenesis of pancreatitis that is a common
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …
Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications
The liver is a crucial metabolic organ that has a key role in maintaining immune and
endocrine homeostasis. Accumulating evidence suggests that chronic liver disease might …
endocrine homeostasis. Accumulating evidence suggests that chronic liver disease might …
Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension
W Tian, X Jiang, R Tamosiuniene, YK Sung… - Science translational …, 2013 - science.org
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-
aged women, and its etiology is poorly understood. A prominent pathological feature of PH …
aged women, and its etiology is poorly understood. A prominent pathological feature of PH …