Mechanisms of decompensation and organ failure in cirrhosis: from peripheral arterial vasodilation to systemic inflammation hypothesis

M Bernardi, R Moreau, P Angeli, B Schnabl… - Journal of hepatology, 2015 - Elsevier
The peripheral arterial vasodilation hypothesis has been most influential in the field of
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …

Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension

M Rabinovitch, C Guignabert, M Humbert… - Circulation …, 2014 - Am Heart Assoc
This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

C Deng, Q Zhang, P He, B Zhou, K He, X Sun… - Nature …, 2021 - nature.com
Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid
arthritis (RA) joints contributes toward the persistent progression of joint inflammation and …

Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases

W He, N Kapate, CW Shields IV, S Mitragotri - Advanced drug delivery …, 2020 - Elsevier
Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction

C Engelmann, J Clària, G Szabo, J Bosch… - Journal of …, 2021 - Elsevier
Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …

Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart

I Vrhovac, D Balen Eror, D Klessen, C Burger… - … -European Journal of …, 2015 - Springer
Novel affinity-purified antibodies against human SGLT1 (hSGLT1) and SGLT2 (hSGLT2)
were used to localize hSGLT2 in human kidney and hSGLT1 in human kidney, small …

[HTML][HTML] Macrophages in pancreatitis: Mechanisms and therapeutic potential

F Hu, N Lou, J Jiao, F Guo, H Xiang, D Shang - Biomedicine & …, 2020 - Elsevier
Macrophages play a crucial role in the pathogenesis of pancreatitis that is a common
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …

Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications

C Matyas, G Haskó, L Liaudet, E Trojnar… - Nature Reviews …, 2021 - nature.com
The liver is a crucial metabolic organ that has a key role in maintaining immune and
endocrine homeostasis. Accumulating evidence suggests that chronic liver disease might …

Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

W Tian, X Jiang, R Tamosiuniene, YK Sung… - Science translational …, 2013 - science.org
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-
aged women, and its etiology is poorly understood. A prominent pathological feature of PH …