Augmentation strategies for treatment resistant major depression: a systematic review and network meta-analysis
Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …
patients with treatment-resistant depression (TRD). We conducted a systematic review and …
Pharmacotherapies for treatment-resistant depression: how antipsychotics fit in the rapidly evolving therapeutic landscape
One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …
significant improvement after multiple sequential courses of antidepressants and have …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
Magnitude of the placebo response across treatment modalities used for treatment-resistant depression in adults: a systematic review and meta-analysis
BDM Jones, LB Razza, CR Weissman, J Karbi… - JAMA network …, 2021 - jamanetwork.com
Importance The placebo effect in depression clinical trials is a substantial factor associated
with failure to establish efficacy of novel and repurposed treatments. However, the …
with failure to establish efficacy of novel and repurposed treatments. However, the …
Efficacy and tolerability of combination treatments for major depression: antidepressants plus second-generation antipsychotics vs. esketamine vs. lithium
Background: Successful treatment of major depressive disorder (MDD) can be challenging,
and failures (" treatment-resistant depression"[TRD]) are frequent. Steps to address TRD …
and failures (" treatment-resistant depression"[TRD]) are frequent. Steps to address TRD …
Efficacy and safety of cariprazine in bipolar I depression: A double‐blind, placebo‐controlled phase 3 study
WR Earley, MV Burgess, B Khan, L Rekeda… - Bipolar …, 2020 - Wiley Online Library
Objective To assess the efficacy, safety, and tolerability of cariprazine in the treatment of the
depressed phase of bipolar I disorder in adults (NCT02670538). Methods In this phase 3 …
depressed phase of bipolar I disorder in adults (NCT02670538). Methods In this phase 3 …
Dopamine receptor partial agonists: Do they differ in their clinical efficacy?
Dopamine receptor partial agonists (DRPAs; aripiprazole, brexpiprazole, and cariprazine)
constitute a novel class of antipsychotics. Although they share a similar mechanism of …
constitute a novel class of antipsychotics. Although they share a similar mechanism of …
Adjunctive cariprazine for the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled phase 3 study
GS Sachs, PP Yeung, L Rekeda… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: The purpose of this study was to investigate the efficacy of cariprazine, a
dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive …
dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive …
Pharmacological interventions for treatment‐resistant depression in adults
Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …
moderate to severe depression, many people do not respond adequately to medication, and …
Cariprazine as a treatment across the bipolar I spectrum from depression to mania: mechanism of action and review of clinical data
SM Stahl, S Laredo… - Therapeutic Advances in …, 2020 - journals.sagepub.com
Cariprazine is one of the newest dopamine-serotonin partial agonists, also known as
'atypical'second generation antipsychotics. Originally approved for acute and maintenance …
'atypical'second generation antipsychotics. Originally approved for acute and maintenance …