Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Gene drive organisms (GDOs), whose genomes have been genetically engineered to
spread a desired allele through a population, have the potential to transform the way …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Synthetic gene drives, inspired by natural selfish genetic elements and transmitted to
progeny at super-Mendelian (> 50%) frequencies, present transformative potential for …

Population-scale genome modification can alter the composition or fate of wild populations.
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …

Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …

Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

Gene drive elements promote the spread of linked traits and can be used to change the
composition or fate of wild populations. Cleave and Rescue (ClvR) drive elements sit at a …

The spread of synthetic gene drives is often discussed in the context of panmictic
populations connected by gene flow and described with simple deterministic models. Under …