Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in
most, if not all, living organisms. In mammals, these transporters chiefly catalyze the …

More than 200 genes annotated as Na+/H+ hydrogen exchangers (NHEs) currently reside in
bioinformation databases such as GenBank and Pfam. We performed detailed phylogenetic …

This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

The NHE family of ion exchangers includes six isoforms (NHE1–NHE6) that function in an
electroneutral exchange of intracellular H+ for extracellular Na+. This review focuses on the …

Four isoforms of the Na+/H+ exchanger (NHE6–NHE9) are distributed to intracellular
compartments in human cells. They are localized to Golgi and post-Golgi endocytic …

Although physiological and biochemical data since long suggested that Na+/H+ and K+/H+
antiporters are involved in intracellular ion and pH regulation in plants, it has taken a long …