Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone
receptor family, attract wide attention as promising therapeutic targets for the treatment of …

Objective: Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts
and deposition of extracellular matrix (ECM) and it is one of the principal reasons for ovarian …

Background Multiple oral insulin-sensitizing agents, such as metformin, thiazolidinediones,
inositols, and berberine, have been proven safe and efficacious in improving the endocrine …

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women who are
of reproductive age. The pathogenesis involves several associated hormonal pathways that …

Reproductive functions may be altered by the exposure to a multitude of endogenous and
exogenous agents, drug or environmental pollutants, which are known to affect gene …

Objective Characteristic features of polycystic ovary syndrome (PCOS) include insulin
resistance and an increased risk for type 2 diabetes. To promote improved insulin sensitivity …

Background: Metformin is effective for the treatment of polycystic ovary syndrome (PCOS),
but conflicting results regarding its impact on serum levels of C-reactive protein (CRP) and …

The oral cavity is considered an attractive site of drug administration. Metformin is currently,
used in oral diabetes treatment. The aim of the current study was to study the feasibility of …

Objective Chronic low-grade inflammation is a common feature of insulin resistant states,
including obesity and type 2 diabetes. Less is known about inflammation in Polycystic Ovary …

Objective To evaluate the effects of berberine on the menstrual pattern, ovulation rate,
hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary …