Membranes are formed from a bilayer containing diverse lipid species with which membrane
proteins interact. Integral, membrane proteins are embedded in this bilayer, where they …

To generate the desired effect in the human body, the active pharmaceutical ingredient
usually needs to interact with a receptor located on the cell membrane or inside the cell …

Integral membrane proteins are regulated by specific interactions with lipids from the
surrounding bilayer. The structures of protein–lipid complexes can be determined through a …

The long-term cryopreservation of cells, tissues and organs is limited by both osmotic stress
and ice injury during freezing or thawing. Introduction of biocompatible cryoprotective agents …

KcsA is a potassium channel with a plethora of structural and functional information, but its
activity in the KcsA-producing actinomycete membranes remains elusive. To determine lipid …

Abstract P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug
resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a …

Membrane proteins (MPs) are affected by binding of specific lipids. We previously
developed a methodology for systematically analyzing MP-lipid interactions leveraging …

S-TGA-1 and PGP-Me are native archaeal lipids associated with the bacteriorhodopsin (bR)
trimer and contribute to protein stabilization and native dynamics for proton transfer …

In biological membranes, lipids often interact with membrane proteins (MPs), regulating the
localization and activity of MPs in cells. Although elucidating lipid–MP interactions is critical …

Although it has been demonstrated that membrane proteins (MPs) require lipids to ensure
their structural and functional integrity, details on how lipid–MP interactions regulate MPs …