Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

[HTML][HTML] Signatures of mitochondrial dysfunction and impaired fatty acid metabolism in plasma of patients with post-acute sequelae of COVID-19 (PASC)

VP Guntur, T Nemkov, E de Boer, MP Mohning… - Metabolites, 2022 - mdpi.com
Exercise intolerance is a major manifestation of post-acute sequelae of severe acute
respiratory syndrome coronavirus infection (PASC, or “long-COVID”). Exercise intolerance in …

The striking mimics between COVID-19 and malaria: A review

EHE Konozy, MEM Osman… - Frontiers in …, 2022 - frontiersin.org
Objectives COVID-19 is a transmissible illness triggered by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Since its onset in late 2019 in Wuhan city of China …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition

MD Galbraith, AL Rachubinski, KP Smith, P Araya… - Science …, 2023 - science.org
Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling.
However, the clinical impacts of interferon hyperactivity in DS are ill-defined. Here, we …

Interferon resistance of emerging SARS-CoV-2 variants

K Guo, BS Barrett, JH Morrison… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and
resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic …

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

M Essex, B Millet Pascual-Leone, U Löber… - npj Biofilms and …, 2024 - nature.com
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis
that disease progression and inflammatory responses associate with alterations in the …

Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

SM Recktenwald, G Simionato, MGM Lopes… - Elife, 2022 - elifesciences.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the …

[HTML][HTML] Biological mechanisms underpinning the development of long COVID

R Perumal, L Shunmugam, K Naidoo, D Wilkins… - Iscience, 2023 - cell.com
As COVID-19 evolves from a pandemic to an endemic disease, the already staggering
number of people that have been or will be infected with SARS-CoV-2 is only destined to …

The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review

G Bellucci, A Albanese, C Rizzi, V Rinaldi… - Frontiers in …, 2023 - frontiersin.org
Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic
rejuvenated the interest in interferon biology in health and disease, opening translational …