Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …
Remodelling the extracellular matrix in development and disease
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …
continuously undergoes controlled remodelling. This process involves quantitative and …
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma
Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to
invasive breast cancer (IBC). To understand the changes in the tumor microenvironment …
invasive breast cancer (IBC). To understand the changes in the tumor microenvironment …
Matrix Metalloproteinases: A challenging paradigm of cancer management
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …
implicated in a variety of physiological and pathological processes. Over the decades …
[HTML][HTML] Cancer associated fibroblasts (CAFs) in tumor microenvironment
F Xing, J Saidou, K Watabe - Frontiers in bioscience: a journal and …, 2010 - ncbi.nlm.nih.gov
Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor
microenvironment which promotes the growth and invasion of cancer cells by various …
microenvironment which promotes the growth and invasion of cancer cells by various …
Matrix metalloproteinases as novel biomarker s and potential therapeutic targets in human cancer
The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
RNA‐binding IMPs promote cell adhesion and invadopodia formation
J Vikesaa, TVO Hansen, L Jønson, R Borup… - The EMBO …, 2006 - embopress.org
Oncofetal RNA‐binding IMPs have been implicated in mRNA localization, nuclear export,
turnover and translational control. To depict the cellular actions of IMPs, we performed a loss …
turnover and translational control. To depict the cellular actions of IMPs, we performed a loss …
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
Bone metastasis is mediated by complex interactions between tumor cells and resident
stromal cells in the bone microenvironment. The functions of metalloproteinases in organ …
stromal cells in the bone microenvironment. The functions of metalloproteinases in organ …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …