Vitamin B12 deficiency

R Green, LH Allen, AL Bjørke-Monsen, A Brito… - Nature reviews Disease …, 2017 - nature.com
Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …

Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing

Y Kurashima, H Kiyono - Annual review of immunology, 2017 - annualreviews.org
The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet,
enteroendocrine, and tuft cells as well as other cell populations, all of which contribute …

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

EA Lopera-Maya, A Kurilshikov, A van der Graaf, S Hu… - Nature …, 2022 - nature.com
Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Y Goto, T Obata, J Kunisawa, S Sato, II Ivanov… - Science, 2014 - science.org
INTRODUCTION The combination of food intake and the resident gut microbiota exposes
the gastrointestinal (GI) tract to numerous antigens. Intestinal epithelial cells (ECs) compose …

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A Franke, DPB McGovern, JC Barrett, K Wang… - Nature …, 2010 - nature.com
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

BL Pierce, H Ahsan… - International journal of …, 2011 - academic.oup.com
Abstract Background Mendelian Randomization (MR) studies assess the causality of an
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …

Distribution and medical impact of loss-of-function variants in the Finnish founder population

ET Lim, P Würtz, AS Havulinna, P Palta… - PLoS …, 2014 - journals.plos.org
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity,
large number and modest effect sizes of associated variants on disease risk and the …

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

JC Chambers, W Zhang, J Sehmi, X Li, MN Wass… - Nature …, 2011 - nature.com
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

[HTML][HTML] Sport nutrigenomics: personalized nutrition for athletic performance

NS Guest, J Horne, SM Vanderhout… - Frontiers in nutrition, 2019 - frontiersin.org
An individual's dietary and supplement strategies can influence markedly their physical
performance. Personalized nutrition in athletic populations aims to optimize health, body …

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

DPB McGovern, MR Jones, KD Taylor… - Human molecular …, 2010 - academic.oup.com
Genetic variation in both innate and adaptive immune systems is associated with Crohn's
disease (CD) susceptibility, but much of the heritability to CD remains unknown. We …