Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …

High-throughput screening identified 5 chemical analogs (termed the WX8-family) that
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …

Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

The review summarizes the advances in medicinal chemistry of tetrazole biologically active
compounds and drugs over the past 15 years. Most of the considered compounds are at …

Computer-aided drug design (CADD), especially artificial intelligence-driven drug design
(AIDD), is increasingly used in drug discovery. In this paper, a novel and efficient workflow …

Most disease-gene association methods do not account for gene-gene interactions, even
though these play a crucial role in complex, polygenic diseases like Alzheimer's disease …