Beyond PI3Ks: targeting phosphoinositide kinases in disease
JE Burke, J Triscott, BM Emerling… - Nature Reviews Drug …, 2023 - nature.com
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
Structural basis for regulation of phosphoinositide kinases and their involvement in human disease
JE Burke - Molecular cell, 2018 - cell.com
Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Phosphoinositides: regulators of nervous system function in health and disease
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …
emerged as regulators of key sub-cellular processes such as membrane transport …
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis
High-throughput screening identified 5 chemical analogs (termed the WX8-family) that
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP
L Palamiuc, JL Johnson, Z Haratipour… - Science …, 2024 - science.org
Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …
Protein homeostasis in aging and cancer
XQ Chen, T Shen, SJ Fang, XM Sun, GY Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
Biologically active compounds and drugs in the tetrazole series
LV Myznikov, SV Vorona, YE Zevatskii - Chemistry of Heterocyclic …, 2021 - Springer
The review summarizes the advances in medicinal chemistry of tetrazole biologically active
compounds and drugs over the past 15 years. Most of the considered compounds are at …
compounds and drugs over the past 15 years. Most of the considered compounds are at …
Hit Identification Driven by Combining Artificial Intelligence and Computational Chemistry Methods: A PI5P4K-β Case Study
L Wei, M Xu, Z Liu, C Jiang, X Lin, Y Hu… - Journal of Chemical …, 2023 - ACS Publications
Computer-aided drug design (CADD), especially artificial intelligence-driven drug design
(AIDD), is increasingly used in drug discovery. In this paper, a novel and efficient workflow …
(AIDD), is increasingly used in drug discovery. In this paper, a novel and efficient workflow …
Identification of risk genes for Alzheimer's disease by gene embedding
Y Lagisetty, T Bourquard, I Al-Ramahi, CG Mangleburg… - Cell genomics, 2022 - cell.com
Most disease-gene association methods do not account for gene-gene interactions, even
though these play a crucial role in complex, polygenic diseases like Alzheimer's disease …
though these play a crucial role in complex, polygenic diseases like Alzheimer's disease …