[HTML][HTML] Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …
structures or functions that are difficult to interfere with using conventional drug design …
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade
ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
[HTML][HTML] Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
S Wu, L Fu - Molecular cancer, 2018 - Springer
Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
[HTML][HTML] LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1
Z Chang, Y Jia, W Zhang, L Song, M Gao, M Li… - Journal of Experimental …, 2018 - Springer
Background This study aims to clarify the underlying mechanism for the tumor suppressive
function of lnc TUSC7 in chemotherapy resistance of esophageal squamous cell carcinoma …
function of lnc TUSC7 in chemotherapy resistance of esophageal squamous cell carcinoma …
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
CP Wu, SH Hsiao, YS Wu - Drug Resistance Updates, 2023 - Elsevier
The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …
[HTML][HTML] Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance
Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …
Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters
ZX He, TQ Zhao, YP Gong, X Zhang, LY Ma… - European Journal of …, 2020 - Elsevier
The multidrug resistance (MDR) phenomenon in cancer cells is the major obstacle leading
to failure of chemotherapy accompanied by the feature of intractable and recurrence of …
to failure of chemotherapy accompanied by the feature of intractable and recurrence of …
ABCG2/BCRP: specific and nonspecific modulators
D Peña‐Solórzano, SA Stark, B König… - Medicinal research …, 2017 - Wiley Online Library
Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …
[HTML][HTML] Voruciclib, a potent CDK4/6 inhibitor, antagonizes ABCB1 and ABCG2-mediated multi-drug resistance in cancer cells
Background/Aims: The overexpression of ATP-Binding Cassette (ABC) transporters has
known to be one of the major obstacles impeding the success of chemotherapy in drug …
known to be one of the major obstacles impeding the success of chemotherapy in drug …
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo
Phosphoinositide 3-kinase gamma isoform (PI3Kγ) plays a critical role in myeloid-derived
cells of the immunosuppressive tumor microenvironment. IPI-549, a recently discovered …
cells of the immunosuppressive tumor microenvironment. IPI-549, a recently discovered …