The biology of TREM receptors

M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

SP Jackson, R Darbousset… - Blood, The Journal of …, 2019 - ashpublications.org
Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

S Sharma, T Tyagi, S Antoniak - Frontiers in immunology, 2022 - frontiersin.org
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Platelets as key players in inflammation and infection

L Nicolai, S Massberg - Current opinion in hematology, 2020 - journals.lww.com
New findings highlight the complex interplay of innate immunity, coagulation and platelets in
inflammation and infection, and unravel novel molecular pathways and effector functions …

Application of lipopolysaccharide in establishing inflammatory models

X Zhang, X Tian, Y Wang, Y Yan, Y Wang, M Su… - International Journal of …, 2024 - Elsevier
Lipopolysaccharide (LPS), a unique component of the outer membrane of Gram-negative
bacteria, possesses immune-activating properties. It induces an immune response by …

Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle

T Dehghani, A Panitch - Open Biology, 2020 - royalsocietypublishing.org
Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for
millions of patients with inflammatory disorders. As late-state consequences of chronic …

Release of α-granule contents during platelet activation

CW Smith - Platelets, 2022 - Taylor & Francis
Upon activation, platelets release a plethora of factors which help to mediate their dynamic
functions in hemostasis, inflammation, wound healing, tumor metastasis and angiogenesis …

Effects of melatonin on protecting against lung injury

W Wang, J Gao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
Abstract Melatonin (MT; N‑acetyl‑5‑methoxy‑tryptamine), which has multiple effects and
roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to …

Platelet count in patients with SARS-CoV-2 infection: a prognostic factor in COVID-19

A Boccatonda, D D'Ardes, I Rossi, A Grignaschi… - Journal of clinical …, 2022 - mdpi.com
COVID-19 patients may manifest thrombocytopenia and some of these patients succumb to
infection due to coagulopathy. The aim of our study was to examine platelet count values in …

A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders

PS Gandhi, M Zivkovic, H Østergaard… - Nature Cardiovascular …, 2024 - nature.com
Inherited bleeding disorders such as Glanzmann thrombasthenia (GT) lack prophylactic
treatment options. As a result, serious bleeding episodes are treated acutely with blood …