Highlights•Liquid-liquid phase separation underlies the formation of membraneless
organelles within cells.•Theory and molecular simulations help to relate interactions at the …

Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …

Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly …

Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an
integrative biophysical approach that includes nuclear magnetic resonance spectroscopy …

Liquid–liquid phase separation of flexible biomolecules has been identified as a ubiquitous
phenomenon underlying the formation of membraneless organelles that harbor a multitude …

Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for
biomolecular condensates underlain by liquid–liquid phase separation (LLPS) of proteins …

Organization of the genome into transcriptionally active euchromatin and silenced
heterochromatin is essential for eukaryotic cell function. Phase-separation has been …

The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …

The role of biomolecular condensates in regulating biological function and the importance of
dynamic interactions involving intrinsically disordered protein regions (IDRs) in their …