Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

From worm to man, many odorant signals are perceived by the binding of volatile ligands to
odorant receptors that belong to the G-protein-coupled receptor (GPCR) family. They couple …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Hyperpolarization‐activated cation currents (Ih) contribute to various physiological
properties and functions in the brain, including neuronal pacemaker activity, setting of …

Hyperpolarization‐activated cation (HCN) channels are believed to be involved in the
generation of cardiac pacemaker depolarizations as well as in the control of neuronal …

The hyperpolarization-activated cation current (termed I h, I q, or I f) was recently shown to
be encoded by a new family of genes, named HCN for h yperpolarization-activated c yclic n …

Hyperpolarization-activated, cyclic nucleotide-gated cation currents, termed If or Ih, are
generated by four members of the hyperpolarization-activated, cyclic nucleotide-gated …