The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Most human epithelial tumors harbor numerous alterations, making it difficult to predict
which genes are required for tumor survival. To systematically identify cancer dependencies …

A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

Next-generation DNA sequencing technologies have led to a massive accumulation of
genomic and transcriptomic data from patients and healthy individuals. The major challenge …

Seminal yeast studies have established the value of comprehensively mapping genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …

A central question in the post-genomic era is how genes interact to form biological
pathways. Measurements of gene dependency across hundreds of cell lines have been …

Integrin αvβ8 binds with exquisite specificity to latent transforming growth factor-β (L-TGF-β).
This binding is essential for activating L-TGF-β presented by a variety of cell types. Inhibiting …

High-throughput genetic screens interfering with gene expression are invaluable tools to
identify gene function and phenotype-to-genotype interactions. Implementing such screens …