Targeted intracellular delivery of antibodies: the state of the art

TA Slastnikova, AV Ulasov, AA Rosenkranz… - Frontiers in …, 2018 - frontiersin.org
A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …

Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies

X Wang, Y Xia - Frontiers in immunology, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy

C Bergua, H Chiavelli, Y Allenbach… - Annals of the …, 2019 - ard.bmj.com
Objectives In autoimmunity, autoantibodies (aAb) may be simple biomarkers of disease or
true pathogenic effectors. A form of idiopathic inflammatory myopathy associated with anti …

Nanobodies as molecular imaging probes

S Barakat, M Berksöz, P Zahedimaram, S Piepoli… - Free Radical Biology …, 2022 - Elsevier
Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Can antinuclear antibodies have a pathogenic role in systemic sclerosis?

A Chepy, L Bourel, V Koether, D Launay… - Frontiers in …, 2022 - frontiersin.org
Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis
of the skin and internal organs, associated with vasculopathy and autoimmune features …

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell‐penetrating peptide: An efficient sonochemical catalytic process

R Taheri‐Ledari, A Maleki - Journal of Peptide Science, 2020 - Wiley Online Library
Herein, we make an effort to enhance the antimicrobial activity of levofloxacin (LVX)
antibiotic via conjugation to a cell‐penetrating peptide (CPP) including Cys‐Gly‐Ala‐Phe …

Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

BM Giles, SA Boackle - Immunologic research, 2013 - Springer
Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ
systems resulting in diverse symptoms and outcomes. It is characterized by antibody …

Autoantibodies to intracellular antigens: generation and pathogenetic role

V Racanelli, M Prete, G Musaraj, F Dammacco… - Autoimmunity …, 2011 - Elsevier
Autoantibodies to intracellular antigens form a large family of immunoglobulins directed to a
variety of ubiquitously expressed intracellular molecules, including numerous enzymes …

Harnessing SLE autoantibodies for intracellular delivery of biologic therapeutics

RE Gordon, JF Nemeth, S Singh, RB Lingham… - Trends in …, 2021 - cell.com
Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for
biomedical research and the pharmaceutical industry. Approximately two-thirds of disease …

Pathophysiological mechanisms and treatment of dermatomyositis and immune mediated necrotizing myopathies: a focused review

RG Kamperman, AJ van der Kooi, M de Visser… - International journal of …, 2022 - mdpi.com
Idiopathic inflammatory myopathies (IIM), collectively known as myositis, are a composite
group of rare autoimmune diseases affecting mostly skeletal muscle, although other organs …