Antimalarial drug resistance and novel targets for antimalarial drug discovery
MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Candida albicans is the most common fungal pathogen of humans and has developed an
extensive repertoire of putative virulence mechanisms that allows successful colonization …
extensive repertoire of putative virulence mechanisms that allows successful colonization …
Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound
The study was planned to screen the marine actinobacterial extract for the protease inhibitor
activity and its anti-Pf activity under in vitro and in vivo conditions. Out of 100 isolates, only 3 …
activity and its anti-Pf activity under in vitro and in vivo conditions. Out of 100 isolates, only 3 …
Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents
Quinoline-containing antimalarial drugs, such as chloroquine, quinine and mefloquine, are
mainstays of chemotherapy against malaria. The molecular basis of the action of these …
mainstays of chemotherapy against malaria. The molecular basis of the action of these …
Cysteine proteases of parasitic organisms
M Sajid, JH McKerrow - Molecular and biochemical parasitology, 2002 - Elsevier
Cysteine proteases play numerous indispensable roles in the biology of parasitic organisms.
Aside from previously known general catabolic functions and protein processing, cysteine …
Aside from previously known general catabolic functions and protein processing, cysteine …
Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design
F Lecaille, J Kaleta, D Brömme - Chemical reviews, 2002 - ACS Publications
Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …
Synthesis and structure− activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
X Du, C Guo, E Hansell, PS Doyle… - Journal of medicinal …, 2002 - ACS Publications
American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in
Latin America. Currently there is an urgent need to develop antitrypanosomal therapy due to …
Latin America. Currently there is an urgent need to develop antitrypanosomal therapy due to …
α2-macroglobulin: an evolutionarily conserved arm of the innate immune system
PB Armstrong, JP Quigley - Developmental & Comparative Immunology, 1999 - Elsevier
All animals and plants have immune systems that protect them from the diversity of
pathogens that would otherwise threaten their survival. The different components of the …
pathogens that would otherwise threaten their survival. The different components of the …
Cysteine proteases of malaria parasites
PJ Rosenthal - International journal for parasitology, 2004 - Elsevier
A number of cysteine proteases of malaria parasites have been described, and many more
putative cysteine proteases are suggested by analysis of the Plasmodium falciparum …
putative cysteine proteases are suggested by analysis of the Plasmodium falciparum …
Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
H Ginsburg, O Famin, J Zhang, M Krugliak - Biochemical pharmacology, 1998 - Elsevier
We propose here a new and detailed model for the antimalarial action of chloroquine (CQ),
based on the its ability to inhibit degradation of heme by glutathione. Heme, which is toxic to …
based on the its ability to inhibit degradation of heme by glutathione. Heme, which is toxic to …