Neurofilaments as biomarkers in neurological disorders

M Khalil, CE Teunissen, M Otto, F Piehl… - Nature Reviews …, 2018 - nature.com
Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Blood neurofilament light: a critical review of its application to neurologic disease

C Barro, T Chitnis, HL Weiner - Annals of clinical and …, 2020 - Wiley Online Library
Neuronal injury is a universal event that occurs in disease processes that affect both the
central and peripheral nervous systems. A blood biomarker linked to neuronal injury would …

An update on diagnostic and prognostic biomarkers for traumatic brain injury

KK Wang, Z Yang, T Zhu, Y Shi… - Expert review of …, 2018 - Taylor & Francis
Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Traumatic brain injuries

K Blennow, DL Brody, PM Kochanek, H Levin… - Nature reviews Disease …, 2016 - nature.com
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

The multifaceted role of neurofilament light chain protein in non-primary neurological diseases

S Abu-Rumeileh, A Abdelhak, M Foschi, L D'Anna… - Brain, 2023 - academic.oup.com
The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

Fluid biomarkers for mild traumatic brain injury and related conditions

H Zetterberg, K Blennow - Nature reviews neurology, 2016 - nature.com
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury

ME Huibregtse, JJ Bazarian, SR Shultz… - … & Biobehavioral Reviews, 2021 - Elsevier
Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …

Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?

VA Guedes, K Kenney, P Shahim, BX Qu, C Lai… - Neurology, 2020 - AAN Enterprises
Objective To measure exosomal and plasma levels of candidate blood biomarkers in
veterans with history of mild traumatic brain injury (mTBI) and test their relationship with …

Post-concussion syndrome and chronic traumatic encephalopathy: narrative review on the neuropathology, neuroimaging and fluid biomarkers

I Mavroudis, D Kazis, R Chowdhury, F Petridis, V Costa… - Diagnostics, 2022 - mdpi.com
Traumatic brain injury is a significant public health issue and represents the main contributor
to death and disability globally among all trauma-related injuries. Martial arts practitioners …

Acute peri‐operative neurocognitive disorders: a narrative review

L Evered, K Atkins, B Silbert, DA Scott - Anaesthesia, 2022 - Wiley Online Library
Peri‐operative neurocognitive disorders are the most common complication experienced by
older individuals undergoing anaesthesia and surgery. Peri‐operative neurocognitive …