Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare
lysosomal storage disorder called Farber disease (FD) and a rare epileptic disorder called …

Objective—Lipids are central to the development of atherosclerotic plaques. Specifically,
which lipids are culprits remains controversial, and promising targets have failed in clinical …

Lysosomal storage diseases (LSDs) are a group of metabolic inborn errors caused by
defective enzymes in the lysosome, resulting in the accumulation of undegraded substrates …

The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Lysosomal storage disorders (LSDs) are a vast group of more than 50 clinically identified
metabolic diseases. They are singly rare, but they affect collectively 1 on 5,000 live births …

Infantile globoid cell leukodystrophy (GLD, Krabbe disease) is a fatal demyelinating disorder
caused by a deficiency in the lysosomal enzyme galactosylceramidase (GALC). GALC …

Major depression is a systems disorder which impairs not only central nervous system
aspects of mood and behavior but also peripheral organ systems. Current views on the …

Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late
nineteenth century, but it was only in the past fifty years that SL research surged in …

Abstract Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into
sphingosine, the backbone of all sphingolipids, to regulate many cellular processes …