ABSTRACT Introduction Calpain-1 and calpain-2 are prototypical classical isoforms of the
calpain family of calcium-activated cysteine proteases. Their substrate proteins participate in …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Highlights•Juvenile developmental Pb exposure impaired rat cognitive ability and induced
apoptotic cell death in hippocampal neurons.•Pb-induced apoptosis in hippocampal …

Mitochondrial and endoplasmic reticulum (ER) are important intracellular organelles. The
sites that mitochondrial and ER are closely related in structure and function are called …

L-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a
hematologic cancer that claims the most lives of pediatric cancer patients. Previously, we …

Acute lymphoblastic leukemia (aLL) is a malignant cancer in the blood and bone marrow
characterized by rapid expansion of lymphoblasts. It is a common pediatric cancer and the …

Despite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia
(aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed …

Methadone is an effective and long-lasting analgesic drug that is also used in medication-
assisted treatment for people with opioid use disorders. Although there is evidence that …

Ischemic and traumatic insults to the central nervous system account for most serious acute
and fatal brain injuries and are usually characterized by primary and secondary damage …

Acute lymphoblastic leukemia (ALL) is a hematologic cancer that mostly affects children. It
accounts for over a quarter of ALL pediatric cancers, causing most of the cancer death …