Selected strategies to fight pathogenic bacteria
A Plotniece, A Sobolev, CT Supuran… - Journal of enzyme …, 2023 - Taylor & Francis
Natural products and analogues are a source of antibacterial drug discovery. Considering
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
Carbonic anhydrase inhibitors as novel antibacterials in the era of antibiotic resistance: where are we now?
Resistance to antibiotic treatment developed by bacteria in humans and animals occurs
when the microorganisms resist treatment with clinically approved antibiotics. Actions must …
when the microorganisms resist treatment with clinically approved antibiotics. Actions must …
Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae
NS Abutaleb, AEM Elhassanny… - Journal of Enzyme …, 2022 - Taylor & Francis
Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence
of resistance development against approved antibiotics. Herein, we report the anti …
of resistance development against approved antibiotics. Herein, we report the anti …
[HTML][HTML] Mucoadhesive brinzolamide-loaded nanofibers for alternative glaucoma treatment
O Cegielska, M Sierakowski, P Sajkiewicz… - European Journal of …, 2022 - Elsevier
Despite the advances in the field of pharmaceutical materials and technology, topical
administration remains a method of choice for the treatment of eye diseases such as …
administration remains a method of choice for the treatment of eye diseases such as …
Coumarins effectively inhibit bacterial α-carbonic anhydrases
Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases
(CAs, EC 4.2. 1.1) but they were not yet investigated for the inhibition of bacterial α-CAs …
(CAs, EC 4.2. 1.1) but they were not yet investigated for the inhibition of bacterial α-CAs …
Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships
M Fantacuzzi, I D'Agostino, S Carradori… - Journal of Enzyme …, 2023 - Taylor & Francis
Vibrio cholerae causes life-threatening infections in low-income countries due to the rise of
antibacterial resistance. Innovative pharmacological targets have been investigated and …
antibacterial resistance. Innovative pharmacological targets have been investigated and …
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae
The development of antibacterial drugs with new mechanisms of action is crucial in
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates
Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and
vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug …
vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug …
Evaluation of 1, 3, 4-thiadiazole carbonic anhydrase inhibitors for gut decolonization of vancomycin-resistant enterococci
Vancomycin-resistant enterococci (VRE), Enterococcus faecium and Enterococcus faecalis,
are high-priority drug-resistant pathogens in need of new therapeutic approaches. VRE …
are high-priority drug-resistant pathogens in need of new therapeutic approaches. VRE …
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors
I D'Agostino, GE Mathew, P Angelini… - Journal of Enzyme …, 2022 - Taylor & Francis
The enormous burden of the COVID-19 pandemic in economic and healthcare terms has
cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate …
cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate …