Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

African sleeping sickness, Chagas disease, and leishmaniasis are life-threatening diseases
that together affect millions of people around the world and are caused by different members …

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem.
Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious …

The nucleoside antibiotic tubercidin displays strong activity against different target
organisms, but it is notoriously toxic to mammalian cells. The effects of tubercidin against T …

Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by
several species of parasites belonging to the family Trypansomatida. The present study …

The study of transporters is highly challenging, as they cannot be isolated or studied in
suspension, requiring a cellular or vesicular system, and, when mediated by more than one …

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

Purines and pyrimidines are essential nutrients for any cell. Most organisms are able to
synthesize their own purines and pyrimidines, but this ability was lost in protozoans that …

Leishmania donovani, an intracellular protozoan parasite, is the causative agent of visceral
leishmaniasis, the most severe form of leishmaniasis in humans. It is becoming increasingly …

Toxoplasma gondii is unable to synthesize purines de novo, instead salvages them from its
environment, inside the host cell, for which they need high affinity carriers. Here, we report …