Natural products for cancer chemotherapy

AL Demain, P Vaishnav - Microbial biotechnology, 2011 - Wiley Online Library
For over 40 years, natural products have served us well in combating cancer. The main
sources of these successful compounds are microbes and plants from the terrestrial and …

Angiogenesis: regulators and clinical applications

S Liekens, E De Clercq, J Neyts - Biochemical pharmacology, 2001 - Elsevier
1Angiogenesis is a fundamental process in reproduction and wound healing. Under these
conditions, neovascularization is tightly regulated. Unregulated angiogenesis may lead to …

Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression

L Holmgren, MS O'reilly, J Folkman - Nature medicine, 1995 - nature.com
In cancer patients, dormant micrometastases are often asymptomatic and clinically
undetectable, for months or years, until relapse. We have studied dormant lung metastases …

The pathogenesis of pterygium: current concepts and their therapeutic implications

J Chui, N Di Girolamo, D Wakefield, MT Coroneo - The ocular surface, 2008 - Elsevier
Pterygium is a disease of the ocular surface that is associated with chronic UV exposure and
is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and …

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

EC Griffith, Z Su, BE Turk, S Chen, YH Chang, Z Wu… - Chemistry & biology, 1997 - cell.com
Background: Angiogenesis, the formation of new blood vessels, is essential for tumor
growth. The inhibition of angiogenesis is therefore emerging as a promising therapy for …

Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470

R Satchi-Fainaro, M Puder, JW Davies, HT Tran… - Nature medicine, 2004 - nature.com
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-
carbamoyl) fumagillol (TNP-470), are thus emerging as a new class of anticancer drugs. In …

Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool.

G Gasparini, AL Harris - Journal of clinical oncology, 1995 - ascopubs.org
PURPOSE To review prognostic and therapeutic applications of angiogenesis research in
breast carcinoma. METHODS We reviewed the (1) biologic role of angiogenesis, particularly …

Angiogenesis inhibition: a review

W Auerbach, R Auerbach - Pharmacology & therapeutics, 1994 - Elsevier
In this review we discuss the concept of anti-angiogenesis, which is the inhibition of
neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on …

Angiogenesis as a target in rheumatoid arthritis

AE Koch - Annals of the rheumatic diseases, 2003 - ard.bmj.com
Angiogenesis, the growth of new blood vessels, is impor-tant in a variety of fibroproliferative
disorders, such as diabetic retinopathy, psoriasis, tumour growth, and rheumatoid arthritis …

[HTML][HTML] A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA. hy926 endothelial cell line

E Aranda, GI Owen - Biological research, 2009 - SciELO Chile
Angiogenesis, the development of new capillary vessels, has a host of clinical
manifestations. The identification of agents that increase or decrease angiogenesis is of …