Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
S Nyberg, NJ Abbott, X Shi, PS Steyger… - Science translational …, 2019 - science.org
Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
Recent advances in local drug delivery to the inner ear
Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
Epithelial cell adhesion molecule aptamer conjugated PEG–PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line …
Targeted delivery of anti-cancer agents exclusively to tumor cells introduces an attractive
strategy because it increases the therapeutic index compared with untargeted drugs …
strategy because it increases the therapeutic index compared with untargeted drugs …
[HTML][HTML] Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
K Xu, B Xu, J Gu, X Wang, D Yu, Y Chen - Theranostics, 2023 - ncbi.nlm.nih.gov
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
Gene therapy for human sensorineural hearing loss
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss
L Li, T Chao, J Brant, B O'Malley Jr, A Tsourkas… - Advanced drug delivery …, 2017 - Elsevier
Sensorineural hearing loss (SNHL) is one of the most common diseases, accounting for
about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic …
about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic …
Multifaceted polymersome platforms: Spanning from self-assembly to drug delivery and protocells
V Balasubramanian, B Herranz-Blanco… - Progress in Polymer …, 2016 - Elsevier
Biologically inspired self-assembly processes of amphiphilic copolymers have received an
increasing attention for creating innovative and highly advanced functional materials for …
increasing attention for creating innovative and highly advanced functional materials for …
Functionalized polymersomes for biomedical applications
Polymersomes are latest entry to the drug carrier systems and have proven their utility to
deliver therapeutic agents to specific tissues/organs due to their versatile polymeric …
deliver therapeutic agents to specific tissues/organs due to their versatile polymeric …
Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance
Progress in drug delivery to the ear has been achieved over the last few years. This review
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …