Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Methods Complete methods are available in the Supplementary Materials. In brief, adults
were eligible for the study if they were admitted to our institution from February 25, 2020, to …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years
and has become a dogma of stem cell research for most types of adult stem cells, including …

Neutrophils are the most abundant circulating leukocytes in humans and the first immune
cells recruited at the site of inflammation. Classically perceived as short-lived effector cells …

Neutrophils are the most abundant peripheral immune cells and thus, are continually
replenished by bone marrow-derived progenitors. Still, how newly identified neutrophil …

Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential
associated to dormancy. Here we identify the cell surface receptor neogenin-1 as …