Peripheral itch sensitization in atopic dermatitis

M Tominaga, K Takamori - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …

An altered skin and gut microbiota are involved in the modulation of itch in atopic dermatitis

CS Moniaga, M Tominaga, K Takamori - Cells, 2022 - mdpi.com
Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD).
An alteration of the microbiota diversity modulates the development and course of AD, eg …

The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis

M Napolitano, F di Vico, A Ruggiero… - Frontiers in …, 2023 - frontiersin.org
Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the
pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation …

Betulin and its derivatives reduce inflammation and COX-2 activity in macrophages

W Szlasa, S Ślusarczyk, I Nawrot-Hadzik, R Abel… - Inflammation, 2023 - Springer
Betulin is a heavily studied natural compound for its use as an anticancer or pro-
regenerative agent. The structural similarity between betulin to steroids gives rise to the idea …

Efficacy and Safety of PF-07038124 in Patients With Atopic Dermatitis and Plaque Psoriasis: A Randomized Clinical Trial

LF Eichenfield, S Tarabar, S Forman… - JAMA …, 2024 - jamanetwork.com
Importance Atopic dermatitis (AD) and plaque psoriasis are inflammatory skin diseases with
unmet need for effective topical treatments with few application site reactions. Objective To …

[PDF][PDF] Molecular mechanisms of luteolin against atopic dermatitis based on network pharmacology and in vivo experimental validation

L Tang, J Gao, X Li, X Cao, B Zhou - Drug Design, Development …, 2022 - Taylor & Francis
Purpose To undercover the underlying mechanisms of luteolin against atopic dermatitis
(AD), clinically characterized by recurrent eczematous lesions and intense itching, based on …

Effects of dupilumab on itch-related events in atopic dermatitis: implications for assessing treatment efficacy in clinical practice

R Kishi, S Toyama, M Tominaga, Y Kamata, E Komiya… - Cells, 2023 - mdpi.com
Dupilumab attenuates itch and skin inflammation in patients with atopic dermatitis (AD).
However, itch-related events that are improved by dupilumab remain unclear. Therefore, the …

Propionate alleviates itch in murine models of atopic dermatitis by modulating sensory TRP channels of dorsal root ganglion

Y Xu, Z Qiu, C Gu, S Yu, S Wang, C Li, X Yao, W Li - Allergy, 2024 - Wiley Online Library
Background Itch is the most common symptom of atopic dermatitis (AD) and significantly
decreases the quality of life. Skin microbiome is involved in AD pathogenesis, whereas its …

Autologous Th2‐polarized lymphocytes induce atopic dermatitis lesions in non‐atopic human skin xenotransplants

A Keren, K Reich, M Bertolini, A Moga, C Riethmüller… - Allergy, 2023 - Wiley Online Library
Background The key signals that suffice to induce atopic dermatitis (AD) in human skin
remain incompletely understood. Also, current mouse models reflect human AD only …

Parnassin, a novel therapeutic peptide, alleviates skin lesions in a DNCB-induced atopic dermatitis mouse model

J Hwang-Bo, K Veerappan, H Moon, TH Lee, KW Lee… - Biomedicines, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease which requires continuous
treatment due to its relapsing nature. The current treatment includes steroids and …