Dysthyroid optic neuropathy: emerging treatment strategies

M Pelewicz-Sowa, P Miśkiewicz - Journal of Endocrinological …, 2023 - Springer
Purpose Dysthyroid optic neuropathy (DON) is a rare sight-threatening complication of
Graves' disease. First-line treatment for DON consists of high-dose intravenous …

Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2× 2 factorial, double-blind, randomised controlled trial

R Rajendram, PN Taylor, VJ Wilson… - The Lancet Diabetes & …, 2018 - thelancet.com
Background Standard treatment for thyroid eye disease is with systemic corticosteroids. We
aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression …

Efficacy of corticosteroids and external beam radiation in the management of moderate to severe thyroid eye disease

CI Zoumalan, KP Cockerham, RE Turbin… - Journal of Neuro …, 2007 - journals.lww.com
Abstract Thyroid Eye Disease (TED, Graves ophthalmopathy, thyroid ophthalmopathy) is the
most common cause of orbital inflammation and proptosis in adults. There is no agreement …

Signal intensity, clinical activity and cross-sectional areas on MRI scans in thyroid eye disease

EJ Mayer, DL Fox, G Herdman, J Hsuan… - European journal of …, 2005 - Elsevier
The signal intensity from inflamed extra-ocular muscles on short tau inversion recovery
(STIR)-sequence magnetic resonance imaging (MRI) is known to correlate with clinical …

Serial STIR magnetic resonance imaging correlates with clinical score of activity in thyroid eye disease

E Mayer, G Herdman, C Burnett, J Kabala, P Goddard… - Eye, 2001 - nature.com
Purpose To assess the correlation between inflammatory activity in extraocular muscles
measured with serial short tau inversion recovery (STIR) sequence magnetic resonance …

Clinical manifestations and treatment outcome of optic neuropathy in thyroid-related orbitopathy

GJ Ben Simon, H Syed, R Douglas… - … Surgery, Lasers and …, 2006 - journals.healio.com
BACKGROUND AND OBJECTIVE To investigate the incidence and outcome of optic
neuropathy associated with thyroid-related orbitopathy. PATIENTS AND METHODS All …

Medial wall decompression for optic neuropathy but lateral wall decompression with fat removal for non vision-threatening indications

JD McCann, RA Goldberg, RL Anderson… - American journal of …, 2006 - ajo.com
There are no clear guidelines for the sequence of treatment of ON, but many therapeutic
options are available. Treatments that have proved to be beneficial in ON are: systemic …

Radiological Staging of Thyroid‐Associated Ophthalmopathy: Comparison of T1 Mapping with Conventional MRI

L Chen, W Chen, HH Chen, Q Wu… - International Journal …, 2020 - Wiley Online Library
Background. Accurate staging of patients with thyroid‐associated ophthalmopathy (TAO) is
crucial for clinical decision. Full cognition of pathologic changes and staging TAO using …

Orbital fat volumetry and water fraction measurements using T2-weighted FSE-IDEAL imaging in patients with thyroid-associated orbitopathy

Y Kaichi, K Tanitame, H Itakura… - American Journal …, 2016 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and
edema and the assessment of extraocular muscles are useful for diagnosing and monitoring …

Safety and efficacy of combined immunosuppression and orbital radiotherapy in thyroid-related restrictive myopathy: two-center experience

NT Chalvatzis, AK Tzamalis… - European Journal …, 2014 - journals.sagepub.com
Purpose To evaluate the safety and efficacy of oral steroids when combined with long-term
oral azathioprine (AZA) and orbital radiotherapy in patients with active thyroid-related …