Signaling pathways are critical modulators of a variety of physiological and pathological
processes, and the abnormal activation of some signaling pathways can contribute to …

Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells
including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which …

Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used
to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory …

It is well-known that stroke is one of the leading causes of death and disability all over the
world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of …

Oleamide compounds purified from green algae have been used for the prevention and
treatment of atherosclerosis, thrombosis, arthritis, and cancer. They function through their …

Saikosaponin A (SSA) is a major triterpenoid saponin isolated from Radix bupleuri (RB), a
widely used Chinese traditional medicine to treat various inflammation-related diseases …

Abstract Sirtuin 3 (Sirt3) is a member of the Sirtuin family proteins and known to regulate
multiple physiological processes such as metabolism and aging. As stroke is an aging …

Neuroinflammation mediated by activation of microglia and interruption of the blood-brain
barrier (BBB) is an important factor that contributes to neuron death and infarct area diffusion …

Several recent studies have suggested seemingly contrasting roles of SIRT2 in
inflammation: Our previous cell culture study has indicated that SIRT2 siRNA-produced …

Aims/hypothesis Recovering functional beta cell mass is a promising approach for future
diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a …