Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019
(COVID-19) illness were available within a year of the pandemic being declared but there …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

ABSTRACT SARS-CoV-2 can enter cells after its spike protein is cleaved by either type II
transmembrane serine proteases (TTSPs), like TMPRSS2, or cathepsins. It is now widely …

There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Ion-exchange chromatography (IEC) is a chromatographic technique commonly used for the
separation of ions and ionizable molecules. Its direct coupling with mass spectrometry has …

Rationale: High circulating galectin-3 is associated with poor outcomes in patients with
coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled …

Coronavirus disease 2019 (COVID-19) increases the risk of thromboembolic events,
especially in patients with severe infections requiring intensive care and cardiorespiratory …

Background Nafamostat mesylate is a potent in vitro antiviral agent that inhibits the host
transmembrane protease serine 2 enzyme used by severe acute respiratory syndrome …

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Following initial infection of airway epithelia, SARS …

Objectives This study aimed to evaluate the antiviral effects and safety of nafamostat in early-
onset patients with coronavirus disease 2019 (COVID-19). Methods In this exploratory …