Mesenchymal stem cell-derived exosomes: applications in regenerative medicine
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …
are then released into the extracellular space through a merging of the multivesicular body …
Immunomodulatory effects of MSCs in bone healing
D Medhat, CI Rodríguez, A Infante - International Journal of Molecular …, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are capable of differentiating into multilineage cells, thus
making them a significant prospect as a cell source for regenerative therapy; however, the …
making them a significant prospect as a cell source for regenerative therapy; however, the …
Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model
Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major
role in tissue repair. Although the production of regulatory cytokines by MSC transplantation …
role in tissue repair. Although the production of regulatory cytokines by MSC transplantation …
[HTML][HTML] A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis
Y Cui, Y Guo, L Kong, J Shi, P Liu, R Li, Y Geng… - Bioactive materials, 2022 - Elsevier
The complex pathogenesis of osteoporosis includes excessive bone resorption, insufficient
bone formation and inadequate vascularization, a combination which is difficult to …
bone formation and inadequate vascularization, a combination which is difficult to …
Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation
Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative
effects, but their role in osteogenesis and the underlying mechanism are yet to be …
effects, but their role in osteogenesis and the underlying mechanism are yet to be …
[HTML][HTML] Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways
Nasopharyngeal carcinoma (NPC), as a unique head and neck cancer type, is particularly
prevalent in certain geographic areas such as eastern Asia. Until now, the therapeutic …
prevalent in certain geographic areas such as eastern Asia. Until now, the therapeutic …
miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice
MicroRNAs emerge as critical post-transcriptional regulators in bone metabolism. We have
previously reported in vitro that miR-21 promotes osteogenesis, while studies have also …
previously reported in vitro that miR-21 promotes osteogenesis, while studies have also …
Advances in animal models for studying bone fracture healing
H Gao, J Huang, Q Wei, C He - Bioengineering, 2023 - mdpi.com
Fracture is a common traumatic injury that is mostly caused by traffic accidents, falls, and
falls from height. Fracture healing is a long-term and complex process, and the mode of …
falls from height. Fracture healing is a long-term and complex process, and the mode of …
Recent progress in engineering mesenchymal stem cell differentiation
A Halim, AD Ariyanti, Q Luo, G Song - Stem cell reviews and reports, 2020 - Springer
Due to the ability to differentiate into variety of cell types, mesenchymal stem cells (MSCs)
hold promise as source in cell-based therapy for treating injured tissue and degenerative …
hold promise as source in cell-based therapy for treating injured tissue and degenerative …
Vasoactive intestinal peptide stimulates bone marrow-mesenchymal stem cells osteogenesis differentiation by activating Wnt/β-catenin signaling pathway and …
L Shi, L Feng, ML Zhu, ZM Yang, TY Wu… - Stem cells and …, 2020 - liebertpub.com
Bone defect regeneration is a complex process that involves the coordination of a variety of
different type of cells. As bone tissues are innervated and rich in nerve fibers, the …
different type of cells. As bone tissues are innervated and rich in nerve fibers, the …